Targeting Of Somatic Hypermutation By immunoglobulin Enhancer And Enhancer-Like Sequences

Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies. SH requires the activation-induced cytidine deaminase (AID) protein and transcription of the mutation target s...

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Detalles Bibliográficos
Autores principales: Buerstedde, Jean-Marie, Alinikula, Jukka, Arakawa, Hiroshi, McDonald, Jessica J., Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972084/
https://www.ncbi.nlm.nih.gov/pubmed/24691034
http://dx.doi.org/10.1371/journal.pbio.1001831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972084/
https://www.ncbi.nlm.nih.gov/pubmed/24691034
http://dx.doi.org/10.1371/journal.pbio.1001831

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