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Targeting Of Somatic Hypermutation By immunoglobulin Enhancer And Enhancer-Like Sequences

Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies. SH requires the activation-induced cytidine deaminase (AID) protein and transcription of the mutation target s...

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Detalles Bibliográficos
Autores principales:	Buerstedde, Jean-Marie, Alinikula, Jukka, Arakawa, Hiroshi, McDonald, Jessica J., Schatz, David G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972084/ https://www.ncbi.nlm.nih.gov/pubmed/24691034 http://dx.doi.org/10.1371/journal.pbio.1001831

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