Klotho has dual protective effects on cisplatin-induced acute kidney injury

Klotho protects the kidney from ischemia-reperfusion injury, but its effect on nephrotoxins is unknown. Here we determined if Klotho protects the kidney from cisplatin toxicity. Cisplatin increased plasma creatinine and induced tubular injury, which were exaggerated in Klotho haplosufficient (Kl/+)...

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Detalles Bibliográficos
Autores principales: Panesso, Monica Chang, Shi, Mingjun, Cho, Han Ju, Paek, Jean, Ye, Jianfeng, Moe, Orson W., Hu, Ming Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972320/
https://www.ncbi.nlm.nih.gov/pubmed/24304882
http://dx.doi.org/10.1038/ki.2013.489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972320/
https://www.ncbi.nlm.nih.gov/pubmed/24304882
http://dx.doi.org/10.1038/ki.2013.489

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