Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

Structures of type-1 human immunodeficiency virus (HIV-1) reverse transcriptase (RT) have been determined in several forms, but only one contains an RNA/DNA hybrid. Here we report three structures of HIV-1 RT complexed with a non-nucleotide RT inhibitor (NNRTI) and an RNA/DNA hybrid. In the presence...

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Detalles Bibliográficos
Autores principales: Lapkouski, Mikalai, Tian, Lan, Miller, Jennifer T., Le Grice, Stuart F. J., Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973182/
https://www.ncbi.nlm.nih.gov/pubmed/23314251
http://dx.doi.org/10.1038/nsmb.2485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973182/
https://www.ncbi.nlm.nih.gov/pubmed/23314251
http://dx.doi.org/10.1038/nsmb.2485

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