The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

Apoptosis of pancreatic beta cells is a feature of type 2 diabetes and its prevention may have therapeutic benefit. High glucose concentrations induce apoptosis of islet cells, and this requires the proapoptotic Bcl-2 homology domain 3 (BH3)-only proteins Bim and Puma. We studied the stress pathways...

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Detalles Bibliográficos
Autores principales: Wali, J A, Rondas, D, McKenzie, M D, Zhao, Y, Elkerbout, L, Fynch, S, Gurzov, E N, Akira, S, Mathieu, C, Kay, T W H, Overbergh, L, Strasser, A, Thomas, H E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973197/
https://www.ncbi.nlm.nih.gov/pubmed/24625983
http://dx.doi.org/10.1038/cddis.2014.88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973197/
https://www.ncbi.nlm.nih.gov/pubmed/24625983
http://dx.doi.org/10.1038/cddis.2014.88

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