Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity

Mutation of p53 is the most common genetic change in human cancer, causing complex effects including not only loss of wild-type function but also gain of novel oncogenic functions (GOF). It is increasingly likely that p53-hotspot mutations may confer different types and magnitudes of GOF, but the ev...

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Detalles Bibliográficos
Autores principales: Xu, J, Wang, J, Hu, Y, Qian, J, Xu, B, Chen, H, Zou, W, Fang, J-Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973211/
https://www.ncbi.nlm.nih.gov/pubmed/24603336
http://dx.doi.org/10.1038/cddis.2014.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973211/
https://www.ncbi.nlm.nih.gov/pubmed/24603336
http://dx.doi.org/10.1038/cddis.2014.75

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