Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo

By screening a collection of one hundred combinations of thiazolidinone compounds, we identified one combination (M4) that synergistically inhibited the growth of H460 and H460/TaxR cells and tumor growth in H460/TaxR xenograft mice. A whole genome microarray assay showed that genes involved in nega...

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Detalles Bibliográficos
Autores principales: Zhang, C, Zhai, S, Li, X, Zhang, Q, Wu, L, Liu, Y, Jiang, C, Zhou, H, Li, F, Zhang, S, Su, G, Zhang, B, Yan, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973217/
https://www.ncbi.nlm.nih.gov/pubmed/24651441
http://dx.doi.org/10.1038/cddis.2014.76

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973217/
https://www.ncbi.nlm.nih.gov/pubmed/24651441
http://dx.doi.org/10.1038/cddis.2014.76

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