Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

Cyclosporin A (CsA) inhibits the opening of the mitochondrial permeability transition pore (MPTP) by interacting with cyclophilin D (CypD) and ameliorates neuronal cell death in the central nervous system against ischemic injury. However, the molecular mechanisms underlying CypD/MPTP opening-mediate...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, S Y, Shim, M S, Kim, K-Y, Weinreb, R N, Wheeler, L A, Ju, W-K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973219/
https://www.ncbi.nlm.nih.gov/pubmed/24603333
http://dx.doi.org/10.1038/cddis.2014.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973219/
https://www.ncbi.nlm.nih.gov/pubmed/24603333
http://dx.doi.org/10.1038/cddis.2014.80

Ejemplares similares