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Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

Cyclosporin A (CsA) inhibits the opening of the mitochondrial permeability transition pore (MPTP) by interacting with cyclophilin D (CypD) and ameliorates neuronal cell death in the central nervous system against ischemic injury. However, the molecular mechanisms underlying CypD/MPTP opening-mediate...

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Detalles Bibliográficos
Autores principales:	Kim, S Y, Shim, M S, Kim, K-Y, Weinreb, R N, Wheeler, L A, Ju, W-K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973219/ https://www.ncbi.nlm.nih.gov/pubmed/24603333 http://dx.doi.org/10.1038/cddis.2014.80

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