Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx...

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Detalles Bibliográficos
Autores principales: Munoz, J L, Rodriguez-Cruz, V, Greco, S J, Ramkissoon, S H, Ligon, K L, Rameshwar, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973225/
https://www.ncbi.nlm.nih.gov/pubmed/24675463
http://dx.doi.org/10.1038/cddis.2014.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973225/
https://www.ncbi.nlm.nih.gov/pubmed/24675463
http://dx.doi.org/10.1038/cddis.2014.111

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