Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer

The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target. However, the relief of feedback inhibition and enhancement of other survival pathways often attenuate the anticancer effects of AKT inhibitors. These compensatory mechanisms are very complicated and r...

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Detalles Bibliográficos
Autores principales: Yang, F, Deng, R, Qian, X-J, Chang, S-H, Wu, X-Q, Qin, J, Feng, G-K, Ding, K, Zhu, X-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973233/
https://www.ncbi.nlm.nih.gov/pubmed/24625973
http://dx.doi.org/10.1038/cddis.2014.43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973233/
https://www.ncbi.nlm.nih.gov/pubmed/24625973
http://dx.doi.org/10.1038/cddis.2014.43

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