Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

Inhibition of human mitochondrial peptide deformylase (HsPDF) depolarizes the mitochondrial membrane, reduces mitochondrial protein translation and causes apoptosis in Burkitt's lymphoma. We showed that HsPDF mRNA and protein levels were overexpressed in cancer cells and primary acute myeloid l...

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Detalles Bibliográficos
Autores principales: Sheth, A, Escobar-Alvarez, S, Gardner, J, Ran, L, Heaney, M L, Scheinberg, D A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973238/
https://www.ncbi.nlm.nih.gov/pubmed/24675470
http://dx.doi.org/10.1038/cddis.2014.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973238/
https://www.ncbi.nlm.nih.gov/pubmed/24675470
http://dx.doi.org/10.1038/cddis.2014.112

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