Cargando…

Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

Inhibition of human mitochondrial peptide deformylase (HsPDF) depolarizes the mitochondrial membrane, reduces mitochondrial protein translation and causes apoptosis in Burkitt's lymphoma. We showed that HsPDF mRNA and protein levels were overexpressed in cancer cells and primary acute myeloid l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sheth, A, Escobar-Alvarez, S, Gardner, J, Ran, L, Heaney, M L, Scheinberg, D A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973238/ https://www.ncbi.nlm.nih.gov/pubmed/24675470 http://dx.doi.org/10.1038/cddis.2014.112

Ejemplares similares

Overexpression of peptide deformylase in breast, colon, and lung cancers
por: Randhawa, Harsharan, et al.
Publicado: (2013)

Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase
por: Martinez-Quinones, Patricia, et al.
Publicado: (2019)

Structure and function of a cyanophage-encoded peptide deformylase
por: Frank, Jeremy A, et al.
Publicado: (2013)

Kinetic control of nascent protein biogenesis by peptide deformylase
por: Bögeholz, Lena A. K., et al.
Publicado: (2021)

Drug forecast – the peptide deformylase inhibitors as antibacterial agents
por: Guay, David R P
Publicado: (2007)

Genome-Wide Identification and in Silico Analysis of Poplar Peptide Deformylases
por: Liu, Chang-Cai, et al.
Publicado: (2012)

Direct and Indirect Inhibition of Salmonella Peptide Deformylase by Nitric Oxide
por: Singhal, Anshika, et al.
Publicado: (2020)

Ligand and Structure-Based Approaches for the Identification of Peptide Deformylase Inhibitors as Antibacterial Drugs
por: Gao, Jian, et al.
Publicado: (2016)

N-Heterocyclic analogues as peptide deformylase inhibitors: Molecular modeling, synthesis and antibacterial evaluation
por: Singh, Anuradha, et al.
Publicado: (2014)

A unique peptide deformylase platform to rationally design and challenge novel active compounds
por: Fieulaine, Sonia, et al.
Publicado: (2016)

Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer
por: Gao, Jian, et al.
Publicado: (2016)

Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation
por: Naor, Noga, et al.
Publicado: (2019)

Corrigendum: A unique peptide deformylase platform to rationally design and challenge novel active compounds
por: Fieulaine, Sonia, et al.
Publicado: (2017)

New Antibiotic Molecules: Bypassing the Membrane Barrier of Gram Negative Bacteria Increases the Activity of Peptide Deformylase Inhibitors
por: Mamelli, Laurent, et al.
Publicado: (2009)

Trapping Conformational States Along Ligand-Binding Dynamics of Peptide Deformylase: The Impact of Induced Fit on Enzyme Catalysis
por: Fieulaine, Sonia, et al.
Publicado: (2011)

How water molecules affect the catalytic activity of hydrolases - A XANES study of the local structures of peptide deformylase
por: Cui, Peixin, et al.
Publicado: (2014)

Discovery of Potential Plant-Derived Peptide Deformylase (PDF) Inhibitors for Multidrug-Resistant Bacteria Using Computational Studies
por: Rampogu, Shailima, et al.
Publicado: (2018)

Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells
por: Peng, Bin, et al.
Publicado: (2014)

Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis
por: Bao, Xiaofeng, et al.
Publicado: (2011)

The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation
por: Grzela, Renata, et al.
Publicado: (2017)

c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis
por: Arango, D, et al.
Publicado: (2003)

N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics
por: Casinelli, Gabriella, et al.
Publicado: (2016)

Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate
por: Yao, Yuxiang, et al.
Publicado: (2013)

Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells
por: Haro, Kurtis J., et al.
Publicado: (2012)

MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites
por: See, Yi Xiang, et al.
Publicado: (2022)

P851: TARGETING GENE DEPENDENCIES IN MYC OVEREXPRESSING MULTIPLE MYELOMA
por: Hasan Bou Issa, L., et al.
Publicado: (2022)

The Role of Apoptosis in the Regulation of Hematopoietic Stem Cells: Overexpression of BCL-2 Increases Both Their Number and Repopulation Potential
por: Domen, Jos, et al.
Publicado: (2000)

Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma
por: Ishida, Chiaki Tsuge, et al.
Publicado: (2017)

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death
por: Granatiero, Veronica, et al.
Publicado: (2019)

MYC—an emerging player in mitochondrial diseases
por: Purhonen, Janne, et al.
Publicado: (2023)

MYC overexpression with its prognostic and clinicopathological significance in breast cancer
por: Qu, Jingkun, et al.
Publicado: (2017)

Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II
por: Al-Zeer, Munir A., et al.
Publicado: (2017)

Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting
por: Sopariwala, Danesh H., et al.
Publicado: (2017)

A Selective Small‐Molecule c‐Myc Degrader Potently Regresses Lethal c‐Myc Overexpressing Tumors
por: Xu, Ying, et al.
Publicado: (2022)

Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria
por: Purhonen, Janne, et al.
Publicado: (2023)

OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases
por: Wu, Wei, et al.
Publicado: (2019)

A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies
por: Freie, Brian, et al.
Publicado: (2023)

Identification of Cytotoxic Drugs That Selectively Target Tumor Cells with MYC Overexpression
por: Frenzel, Anna, et al.
Publicado: (2011)

ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
por: Najnin, Rifat Ara, et al.
Publicado: (2023)

MYC is downregulated by a mitochondrial checkpoint mechanism
por: Zhang, Xiaonan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i0sjad4sqegf73mlal5l5pg17j