Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression

Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-responsiveness to growth inhibitory signals. Both genetic and epigenetic changes can contribute to cancer development and prog...

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Detalles Bibliográficos
Autores principales: Gordon, Katrina, Clouaire, Thomas, Bao, Xun X., Kemp, Sadie E., Xenophontos, Maria, de Las Heras, Jose Ignacio, Stancheva, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973294/
https://www.ncbi.nlm.nih.gov/pubmed/24371281
http://dx.doi.org/10.1093/nar/gkt1351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973294/
https://www.ncbi.nlm.nih.gov/pubmed/24371281
http://dx.doi.org/10.1093/nar/gkt1351

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