Length-dependent processing of telomeres in the absence of telomerase

In the absence of telomerase, telomeres progressively shorten with every round of DNA replication, leading to replicative senescence. In telomerase-deficient Saccharomyces cerevisiae, the shortest telomere triggers the onset of senescence by activating the DNA damage checkpoint and recruiting homolo...

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Detalles Bibliográficos
Autores principales: Fallet, Emilie, Jolivet, Pascale, Soudet, Julien, Lisby, Michael, Gilson, Eric, Teixeira, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973311/
https://www.ncbi.nlm.nih.gov/pubmed/24393774
http://dx.doi.org/10.1093/nar/gkt1328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973311/
https://www.ncbi.nlm.nih.gov/pubmed/24393774
http://dx.doi.org/10.1093/nar/gkt1328

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