Sugar-modified G-quadruplexes: effects of LNA-, 2′F-RNA– and 2′F-ANA-guanosine chemistries on G-quadruplex structure and stability

G-quadruplex-forming oligonucleotides containing modified nucleotide chemistries have demonstrated promising pharmaceutical potential. In this work, we systematically investigate the effects of sugar-modified guanosines on the structure and stability of a (4+0) parallel and a (3+1) hybrid G-quadrupl...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhe, Lech, Christopher Jacques, Phan, Anh Tuân
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973314/
https://www.ncbi.nlm.nih.gov/pubmed/24371274
http://dx.doi.org/10.1093/nar/gkt1312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973314/
https://www.ncbi.nlm.nih.gov/pubmed/24371274
http://dx.doi.org/10.1093/nar/gkt1312

Ejemplares similares