CpG domains downstream of TSSs promote high levels of gene expression

CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Infla...

Descripción completa

Detalles Bibliográficos
Autores principales: Krinner, Simone, Heitzer, Asli P., Diermeier, Sarah D., Obermeier, Ingrid, Längst, Gernot, Wagner, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://www.ncbi.nlm.nih.gov/pubmed/24413563
http://dx.doi.org/10.1093/nar/gkt1358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973331/
https://www.ncbi.nlm.nih.gov/pubmed/24413563
http://dx.doi.org/10.1093/nar/gkt1358

Ejemplares similares