Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2

NIR (novel INHAT repressor) can bind to p53 at promoters and inhibit p53-mediated gene transactivation by blocking histone acetylation carried out by p300/CBP. Like NIR, the E3 ubiquitin ligase MDM2 can also bind and inhibit p53 at promoters. Here, we present data indicating that NIR, which shuttles...

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Detalles Bibliográficos
Autores principales: Heyne, Kristina, Förster, Juliane, Schüle, Roland, Roemer, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973334/
https://www.ncbi.nlm.nih.gov/pubmed/24413661
http://dx.doi.org/10.1093/nar/gkt1371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973334/
https://www.ncbi.nlm.nih.gov/pubmed/24413661
http://dx.doi.org/10.1093/nar/gkt1371

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