The Toll-Like Receptor 4 Polymorphism Asp299Gly but Not Thr399Ile Influences TLR4 Signaling and Function

The common, co-segregating Toll-like receptor 4 (TLR4) non-synonymous single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile, are associated with hyporesponsiveness to inhaled lipopolysaccharide (LPS) and increased susceptibility to Gram negative pathogens in humans. The purpose of this stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Huaicong, O'Connor, Brian P., Zemans, Rachel L., Zhou, Xiaofang, Yang, Ivana V., Schwartz, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973565/
https://www.ncbi.nlm.nih.gov/pubmed/24695807
http://dx.doi.org/10.1371/journal.pone.0093550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973565/
https://www.ncbi.nlm.nih.gov/pubmed/24695807
http://dx.doi.org/10.1371/journal.pone.0093550

Ejemplares similares