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The Toll-Like Receptor 4 Polymorphism Asp299Gly but Not Thr399Ile Influences TLR4 Signaling and Function

The common, co-segregating Toll-like receptor 4 (TLR4) non-synonymous single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile, are associated with hyporesponsiveness to inhaled lipopolysaccharide (LPS) and increased susceptibility to Gram negative pathogens in humans. The purpose of this stu...

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Detalles Bibliográficos
Autores principales:	Long, Huaicong, O'Connor, Brian P., Zemans, Rachel L., Zhou, Xiaofang, Yang, Ivana V., Schwartz, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973565/ https://www.ncbi.nlm.nih.gov/pubmed/24695807 http://dx.doi.org/10.1371/journal.pone.0093550

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