A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor

Class B G protein-coupled receptors (GPCRs) are important regulators of endocrine physiology, and peptide-based therapeutics targeting some of these receptors have proven effective at treating disorders such as hypercalcemia, osteoporosis, and type 2 diabetes mellitus (T2DM). As next generation effo...

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Detalles Bibliográficos
Autores principales: Jun, Lucy S., Showalter, Aaron D., Ali, Nosher, Dai, Feihan, Ma, Wenzhen, Coskun, Tamer, Ficorilli, James V., Wheeler, Michael B., Michael, M. Dodson, Sloop, Kyle W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973576/
https://www.ncbi.nlm.nih.gov/pubmed/24695667
http://dx.doi.org/10.1371/journal.pone.0093746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973576/
https://www.ncbi.nlm.nih.gov/pubmed/24695667
http://dx.doi.org/10.1371/journal.pone.0093746

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