Cargando…

Intravitreal Injection of IGFBP-3 Restores Normal Insulin Signaling in Diabetic Rat Retina

Diabetes-induced changes in growth factor binding protein 3 (IGFBP-3) and tumor necrosis factor alpha (TNFα) have been linked to decreased insulin receptor signaling in diabetic retinopathy. Our previous studies in retinas of diabetic rats have shown that Compound 49b, a novel β-adrenergic receptor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Youde, Zhang, Qiuhua, Steinle, Jena J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973588/ https://www.ncbi.nlm.nih.gov/pubmed/24695399 http://dx.doi.org/10.1371/journal.pone.0093788

Ejemplares similares

Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice
por: Jiang, Youde, et al.
Publicado: (2014)

IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels
por: Zhang, Qiuhua, et al.
Publicado: (2015)

Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina
por: Jiang, Youde, et al.
Publicado: (2020)

β1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo
por: Jiang, Youde, et al.
Publicado: (2014)

Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion
por: Liu, Li, et al.
Publicado: (2016)

Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines
por: Curtiss, Elizabeth, et al.
Publicado: (2018)

Erratum to “Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines”
por: Curtiss, Elizabeth, et al.
Publicado: (2019)

Sodium Salicylate Reduced Insulin Resistance in the Retina of a Type 2 Diabetic Rat Model
por: Jiang, Youde, et al.
Publicado: (2015)

Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins
por: Liu, Li, et al.
Publicado: (2017)

Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature
por: Jiang, Youde, et al.
Publicado: (2018)

Glycyrrhizin Protects the Diabetic Retina against Permeability, Neuronal, and Vascular Damage through Anti-Inflammatory Mechanisms
por: Liu, Li, et al.
Publicado: (2019)

Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina
por: Liu, Li, et al.
Publicado: (2019)

Epac1 protects the retina against ischemia/reperfusion-induced neuronal and vascular damage
por: Liu, Li, et al.
Publicado: (2018)

Reduced insulin receptor signaling in retinal Müller cells cultured in high glucose
por: Jiang, Youde, et al.
Publicado: (2013)

TNFα Inhibits IGFBP-3 through Activation of p38α and Casein Kinase 2 in Human Retinal Endothelial Cells
por: Zhang, Qiuhua, et al.
Publicado: (2014)

β-adrenergic receptor agonist, Compound 49b, inhibits TLR4 signaling pathway in diabetic retina
por: Berger, Elizabeth A., et al.
Publicado: (2016)

Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line
por: Jiang, Youde, et al.
Publicado: (2014)

β2-Adrenergic Receptor Knockout Mice Exhibit A Diabetic Retinopathy Phenotype
por: Jiang, Youde, et al.
Publicado: (2013)

Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions
por: Zhang, Qiuhua, et al.
Publicado: (2013)

A regulatory role for β-adrenergic receptors regarding the resolvin D1 (RvD1) pathway in the diabetic retina
por: Shi, Haoshen, et al.
Publicado: (2017)

Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells
por: Jiang, Youde, et al.
Publicado: (2019)

Epac1 Requires AMPK Phosphorylation to Regulate HMGB1 in the Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2020)

Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection
por: Wong, Lily L., et al.
Publicado: (2013)

Pioglitazone alters monocyte populations and stimulates recent thymic emigrants in the BBDZR/Wor type 2 diabetes rat model
por: Gao, Bradley T., et al.
Publicado: (2015)

Correction: Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection
por: Wong, Lily L., et al.
Publicado: (2013)

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

Forskolin eye drops improve retinal damage from ischemia/reperfusion
por: Liu, Li, et al.
Publicado: (2021)

PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature
por: Liu, Li, et al.
Publicado: (2022)

Prohibitin 1 Regulates Inflammatory Mediators and Reactive Oxygen Species in Retinal Endothelial Cells
por: Liu, Li, et al.
Publicado: (2022)

TNFAIP3 is anti-inflammatory in the retinal vasculature
por: Liu, Li, et al.
Publicado: (2022)

Epac1 and PKA agonists inhibit ROS to reduce NLRP3 inflammasome proteins in retinal endothelial cells
por: Liu, Li, et al.
Publicado: (2022)

Impact of Intravitreal Injection of Bevacizumab (Avastin) on Rabbit's Choroid and Retina
por: Karawya, Sherif, et al.
Publicado: (2008)

A protocol for the retina surgeon’s safe initial intravitreal injections
por: Frenkel, Ronald EP, et al.
Publicado: (2010)

Survey of intravitreal injection techniques among retina specialists in Israel
por: Segal, Ori, et al.
Publicado: (2016)

Survey of Intravitreal Injection Techniques Among Retina Specialists in Mexico
por: Henaine-Berra, Andree, et al.
Publicado: (2020)

Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β(1)-adrenergic receptor knockout mouse
por: Panjala, Surekha Rani, et al.
Publicado: (2011)

Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

Restoration of foveal photoreceptors after intravitreal ranibizumab injections for diabetic macular edema
por: Mori, Yuki, et al.
Publicado: (2016)

Editorial: The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease
por: Takahashi, Shin-Ichiro, et al.
Publicado: (2022)

Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
por: Pérez-Acuña, Dayana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hcr5qgi05vuracde73avluhek2