Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice

OBJECTIVES: ACAT2 is the exclusive cholesterol-esterifying enzyme in hepatocytes and enterocytes. Hepatic ABCA1 transfers unesterified cholesterol (UC) to apoAI, thus generating HDL. By changing the hepatic UC pool available for ABCA1, ACAT2 may affect HDL metabolism. The aim of this study was to re...

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Detalles Bibliográficos
Autores principales: Pedrelli, Matteo, Davoodpour, Padideh, Degirolamo, Chiara, Gomaraschi, Monica, Graham, Mark, Ossoli, Alice, Larsson, Lilian, Calabresi, Laura, Gustafsson, Jan-Åke, Steffensen, Knut R., Eriksson, Mats, Parini, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973598/
https://www.ncbi.nlm.nih.gov/pubmed/24695360
http://dx.doi.org/10.1371/journal.pone.0093552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973598/
https://www.ncbi.nlm.nih.gov/pubmed/24695360
http://dx.doi.org/10.1371/journal.pone.0093552

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