Cargando…

Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice

OBJECTIVES: ACAT2 is the exclusive cholesterol-esterifying enzyme in hepatocytes and enterocytes. Hepatic ABCA1 transfers unesterified cholesterol (UC) to apoAI, thus generating HDL. By changing the hepatic UC pool available for ABCA1, ACAT2 may affect HDL metabolism. The aim of this study was to re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pedrelli, Matteo, Davoodpour, Padideh, Degirolamo, Chiara, Gomaraschi, Monica, Graham, Mark, Ossoli, Alice, Larsson, Lilian, Calabresi, Laura, Gustafsson, Jan-Åke, Steffensen, Knut R., Eriksson, Mats, Parini, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973598/ https://www.ncbi.nlm.nih.gov/pubmed/24695360 http://dx.doi.org/10.1371/journal.pone.0093552

Ejemplares similares

HDL‐mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition
por: Ossoli, Alice, et al.
Publicado: (2022)

Air Pollution: Another Threat to HDL Function
por: Ossoli, Alice, et al.
Publicado: (2022)

Protective Effects of HDL Against Ischemia/Reperfusion Injury
por: Gomaraschi, Monica, et al.
Publicado: (2016)

eNOS Activation by HDL Is Impaired in Genetic CETP Deficiency
por: Gomaraschi, Monica, et al.
Publicado: (2014)

The Thyroid Receptor Modulator KB3495 Reduces Atherosclerosis Independently of Total Cholesterol in the Circulation in ApoE Deficient Mice
por: Mörk, Lisa-Mari, et al.
Publicado: (2013)

HDL and chronic kidney disease
por: Pavanello, Chiara, et al.
Publicado: (2023)

Effect of the amyloidogenic L75P apolipoprotein A-I variant on HDL subpopulations
por: Gomaraschi, Monica, et al.
Publicado: (2011)

Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids
por: Othman, Alaa, et al.
Publicado: (2023)

Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein
por: Davoodpour, Padideh, et al.
Publicado: (2007)

Los brujos de Acatic /
por: González Pérez, Ana Rosa
Publicado: (2003)

Abnormal Lipoproteins Trigger Oxidative Stress-Mediated Apoptosis of Renal Cells in LCAT Deficiency
por: Gomaraschi, Monica, et al.
Publicado: (2023)

Neuroprotective efficacy of ABCA1 and HDL in aging rats with cerebrovascular hypoperfusion
por: Wang, Linhui, et al.
Publicado: (2012)

Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans
por: Pavanello, Chiara, et al.
Publicado: (2022)

In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL
por: Franssen, Remco, et al.
Publicado: (2012)

An Overview of Brevinin Superfamily: Structure, Function and Clinical Perspectives
por: Savelyeva, Anna, et al.
Publicado: (2014)

Adrenal Function in Females with Low Plasma HDL-C Due to Mutations in ABCA1 and LCAT
por: Bochem, Andrea E., et al.
Publicado: (2014)

Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes
por: Tsujita, Maki, et al.
Publicado: (2017)

Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism
por: Howard, Alicia D., et al.
Publicado: (2019)

ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke
por: Li, Li, et al.
Publicado: (2020)

Body Mass Index Modulates the Impact of Short-Term Exposure to Air Particulate Matter on High-Density Lipoprotein Function
por: Ossoli, Alice, et al.
Publicado: (2022)

Effects of Caprylic Acid and Eicosapentaenoic Acid on Lipids, Inflammatory Levels, and the JAK2/STAT3 Pathway in ABCA1-Deficient Mice and ABCA1 Knock-Down RAW264.7 Cells
por: Zhang, Xinsheng, et al.
Publicado: (2023)

Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients
por: Ahmed, Osman, et al.
Publicado: (2018)

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway
por: Pamir, Nathalie, et al.
Publicado: (2016)

High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
por: Ossoli, Alice, et al.
Publicado: (2016)

High-Density Lipoproteins and the Kidney
por: Strazzella, Arianna, et al.
Publicado: (2021)

Interactions of Six SNPs in ABCA1gene and Obesity in Low HDL-C Disease in Kazakh of China
por: Yao, Ming-hong, et al.
Publicado: (2016)

Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation
por: Ishigami, Masato, et al.
Publicado: (2018)

Interaction between SIDT2 and ABCA1 Variants with Nutrients on HDL-c Levels in Mexican Adults
por: León-Reyes, Guadalupe, et al.
Publicado: (2023)

Analysis of HDL-microRNA panel in heterozygous familial hypercholesterolemia subjects with LDL receptor null or defective mutation
por: Scicali, Roberto, et al.
Publicado: (2019)

HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE(-/-) Mice: Evidence of ABCA1 Down-Regulation
por: Tardy, Claudine, et al.
Publicado: (2015)

Insulin promotes progression of colon cancer by upregulation of ACAT1
por: Chen, Xin, et al.
Publicado: (2018)

Will Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL?
por: Niesor, Eric J.
Publicado: (2015)

Correlation Between ABCA1 Gene Polymorphism and aopA-I and HDL-C in Abdominal Aortic Aneurysm
por: Zhao, Lingfeng, et al.
Publicado: (2016)

Multiple splice defects in ABCA1 cause low HDL-C in a family with Hypoalphalipoproteinemia and premature coronary disease
por: Rhyne, Jeffrey, et al.
Publicado: (2009)

The Effects of Rope Training on Lymphocyte ABCA1 Expression, Plasma ApoA-I and HDL-c in Boy Adolescents
por: Ghorbanian, Bahloul, et al.
Publicado: (2013)

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism
por: Gnocchi, Davide, et al.
Publicado: (2015)

Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I
por: Hossain, Mohammad A, et al.
Publicado: (2012)

A Novel Nonsense Mutation of ABCA8 in a Han-Chinese Family With ASCVD Leads to the Reduction of HDL-c Levels
por: Wang, Chen-Yu, et al.
Publicado: (2020)

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression
por: Li, Luxiao, et al.
Publicado: (2022)

16th International workshop on Advanced Computing and Analysis Techniques in physics (ACAT)
por: Fiala, L, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_94f199eer421mpkkqoc4u6iutj