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Lesions of the Lateral Habenula Increase Voluntary Ethanol Consumption and Operant Self-Administration, Block Yohimbine-Induced Reinstatement of Ethanol Seeking, and Attenuate Ethanol-Induced Conditioned Taste Aversion

The lateral habenula (LHb) plays an important role in learning driven by negative outcomes. Many drugs of abuse, including ethanol, have dose-dependent aversive effects that act to limit intake of the drug. However, the role of the LHb in regulating ethanol intake is unknown. In the present study, w...

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Detalles Bibliográficos
Autores principales: Haack, Andrew K., Sheth, Chandni, Schwager, Andrea L., Sinclair, Michael S., Tandon, Shashank, Taha, Sharif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973636/
https://www.ncbi.nlm.nih.gov/pubmed/24695107
http://dx.doi.org/10.1371/journal.pone.0092701