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Evolutionary Origins of C-Terminal (GPP)n 3-Hydroxyproline Formation in Vertebrate Tendon Collagen

Approximately half the proline residues in fibrillar collagen are hydroxylated. The predominant form is 4-hydroxyproline, which helps fold and stabilize the triple helix. A minor form, 3-hydroxyproline, still has no clear function. Using peptide mass spectrometry, we recently revealed several previo...

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Detalles Bibliográficos
Autores principales: Hudson, David M., Werther, Rachel, Weis, MaryAnn, Wu, Jiann-Jiu, Eyre, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973637/
https://www.ncbi.nlm.nih.gov/pubmed/24695516
http://dx.doi.org/10.1371/journal.pone.0093467