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The differential processing of telomeres in response to increased telomeric transcription and RNA–DNA hybrid accumulation

Telomeres are protective nucleoprotein structures at the ends of eukaryotic chromosomes. Despite the heterochromatic state of telomeres they are transcribed, generating non-coding telomeric repeat-containing RNA (TERRA). Strongly induced TERRA transcription has been shown to cause telomere shortenin...

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Detalles Bibliográficos
Autores principales: Balk, Bettina, Dees, Martina, Bender, Katharina, Luke, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973735/
https://www.ncbi.nlm.nih.gov/pubmed/24525824
http://dx.doi.org/10.4161/rna.27798