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Aspirin-triggered 15-epi-lipoxin A(4) predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test
Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin H(2). When acetylated by aspirin, however, COX-2 (but not COX-1) can form 15(R...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Federation of American Societies for Experimental Biology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973905/ https://www.ncbi.nlm.nih.gov/pubmed/23792301 http://dx.doi.org/10.1096/fj.12-215533 |