TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells

BACKGROUND: CD248 is a cell surface glycoprotein, highly expressed by stromal cells and fibroblasts of tumors and inflammatory lesions, but virtually undetectable in healthy adult tissues. CD248 promotes tumorigenesis, while lack of CD248 in mice confers resistance to tumor growth. Mechanisms by whi...

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Detalles Bibliográficos
Autores principales: Suresh Babu, Sahana, Valdez, Yanet, Xu, Andrea, O’Byrne, Alice M, Calvo, Fernando, Lei, Victor, Conway, Edward M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974058/
https://www.ncbi.nlm.nih.gov/pubmed/24555435
http://dx.doi.org/10.1186/1471-2407-14-113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974058/
https://www.ncbi.nlm.nih.gov/pubmed/24555435
http://dx.doi.org/10.1186/1471-2407-14-113

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