Cargando…

TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells

BACKGROUND: CD248 is a cell surface glycoprotein, highly expressed by stromal cells and fibroblasts of tumors and inflammatory lesions, but virtually undetectable in healthy adult tissues. CD248 promotes tumorigenesis, while lack of CD248 in mice confers resistance to tumor growth. Mechanisms by whi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suresh Babu, Sahana, Valdez, Yanet, Xu, Andrea, O’Byrne, Alice M, Calvo, Fernando, Lei, Victor, Conway, Edward M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974058/ https://www.ncbi.nlm.nih.gov/pubmed/24555435 http://dx.doi.org/10.1186/1471-2407-14-113

Ejemplares similares

TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
por: Ríos-López, Diana G., et al.
Publicado: (2023)

SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways
por: Liu, Lu, et al.
Publicado: (2021)

SMAD4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis
por: Du, Xing, et al.
Publicado: (2018)

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback
por: Gu, Wenchao, et al.
Publicado: (2015)

TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer
por: Singha, Prajjal K., et al.
Publicado: (2014)

Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2
por: Zboralski, Dirk, et al.
Publicado: (2010)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

Exploring the therapeutic potential of mitochondrial uncouplers in cancer
por: Shrestha, Riya, et al.
Publicado: (2021)

Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer
por: Poursani, Ensieh M., et al.
Publicado: (2023)

TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways
por: Zhao, Yuanyuan, et al.
Publicado: (2018)

An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells
por: Lieberman, Nicole A. P., et al.
Publicado: (2018)

Endothelial Nogo-B Suppresses Cancer Cell Proliferation via a Paracrine TGF-β/Smad Signaling
por: Li, Hengyu, et al.
Publicado: (2022)

The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer
por: Zhang, Yang, et al.
Publicado: (2019)

Cd248a and Cd248b in zebrafish participate in innate immune responses
por: Li, Xianpeng, et al.
Publicado: (2022)

CD248: A therapeutic target in cancer and fibrotic diseases
por: Teicher, Beverly A.
Publicado: (2019)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway
por: Murai, Fumihiko, et al.
Publicado: (2015)

Pregnancy‐specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF‐β/Smad signaling to drive breast cancer progression
por: Liu, Ying‐Ying, et al.
Publicado: (2020)

Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1
por: de Potter, Bastiaan, et al.
Publicado: (2023)

AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells
por: Zou, Junrong, et al.
Publicado: (2021)

Roles of TGFβ signaling Smads in squamous cell carcinoma
por: Han, Gangwen, et al.
Publicado: (2011)

The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma
por: Zhang, Keying, et al.
Publicado: (2021)

Prognostic Impact of Canonical TGF-β Signaling in Urothelial Bladder Cancer
por: Stojnev, Slavica, et al.
Publicado: (2019)

CD248 facilitates tumor growth via its cytoplasmic domain
por: Maia, Margarida, et al.
Publicado: (2011)

Cinobufacini Inhibits the Development of Pancreatic Cancer Cells through the TGFβ/Smads Pathway of Pancreatic Stellate Cells
por: Li, Quan-Wang, et al.
Publicado: (2022)

MicroRNA-362 negatively and positively regulates SMAD4 expression in TGF-β/SMAD signaling to suppress cell migration and invasion
por: Cheng, Han Ping, et al.
Publicado: (2021)

Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells
por: Xia, Wei, et al.
Publicado: (2017)

Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
por: Stolfi, Carmine, et al.
Publicado: (2020)

LHPP suppresses colorectal cancer cell migration and invasion in vitro and in vivo by inhibiting Smad3 phosphorylation in the TGF-β pathway
por: Hou, Bin, et al.
Publicado: (2021)

Health Tract, No. 248: Weights and Measures
Publicado: (1866)

CD248(+) Cancer-Associated Fibroblasts: A Novel Prognostic and Therapeutic Target for Renal Cell Carcinoma
por: Xu, Chao, et al.
Publicado: (2021)

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
por: Ivanova, Koni, et al.
Publicado: (2018)

Pirfenidone suppressed triple‐negative breast cancer metastasis by inhibiting the activity of the TGF‐β/SMAD pathway
por: Luo, Daiqin, et al.
Publicado: (2023)

TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
por: Zhang, Chao, et al.
Publicado: (2017)

TMEM158 Regulates the Canonical and Non-Canonical Pathways of TGF-β to Mediate EMT in Triple-Negative Breast Cancer
por: Tong, Jiaci, et al.
Publicado: (2022)

Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway
por: Du, Haiyan, et al.
Publicado: (2021)

KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression
por: Ali, A, et al.
Publicado: (2015)

Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling
por: Wang, Yanqiu, et al.
Publicado: (2018)

Babao Dan inhibits the migration and invasion of gastric cancer cells by suppressing epithelial–mesenchymal transition through the TGF-β/Smad pathway
por: Liu, Jianxin, et al.
Publicado: (2020)

Inhibition of Ep3 attenuates migration and promotes apoptosis of non-small cell lung cancer cells via suppression of TGF-β/Smad signaling
por: Li, Lei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4888loh9rams5k017uj654aeie