Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition

The purpose of our study was to compare two acquired muscle atrophies and the use of myostatin inhibition for their treatment. Myostatin naturally inhibits skeletal muscle growth by binding to ActRIIB, a receptor on the cell surface of myofibers. Because blocking myostatin in an adult wild-type mous...

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Detalles Bibliográficos
Autores principales: MacDonald, Elizabeth M., Andres-Mateos, Eva, Mejias, Rebeca, Simmers, Jessica L., Mi, Ruifa, Park, Jae-Sung, Ying, Stephanie, Hoke, Ahmet, Lee, Se-Jin, Cohn, Ronald D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974457/
https://www.ncbi.nlm.nih.gov/pubmed/24504412
http://dx.doi.org/10.1242/dmm.014126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974457/
https://www.ncbi.nlm.nih.gov/pubmed/24504412
http://dx.doi.org/10.1242/dmm.014126

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