The Mechanism of Gene Targeting in Human Somatic Cells

Gene targeting in human somatic cells is of importance because it can be used to either delineate the loss-of-function phenotype of a gene or correct a mutated gene back to wild-type. Both of these outcomes require a form of DNA double-strand break (DSB) repair known as homologous recombination (HR)...

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Detalles Bibliográficos
Autores principales: Kan, Yinan, Ruis, Brian, Lin, Sherry, Hendrickson, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974634/
https://www.ncbi.nlm.nih.gov/pubmed/24699519
http://dx.doi.org/10.1371/journal.pgen.1004251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974634/
https://www.ncbi.nlm.nih.gov/pubmed/24699519
http://dx.doi.org/10.1371/journal.pgen.1004251

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