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Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible
Current practice in the normalization of microbiome count data is inefficient in the statistical sense. For apparently historical reasons, the common approach is either to use simple proportions (which does not address heteroscedasticity) or to use rarefying of counts, even though both of these appr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974642/ https://www.ncbi.nlm.nih.gov/pubmed/24699258 http://dx.doi.org/10.1371/journal.pcbi.1003531 |