DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

Whole genome sequencing of cancer genomes has revealed a diversity of recurrent gross chromosomal rearrangements (GCRs) that are likely signatures of specific defects in DNA damage response pathways. However, inferring the underlying defects has been difficult due to insufficient information relatin...

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Detalles Bibliográficos
Autores principales: Putnam, Christopher D., Pallis, Katielee, Hayes, Tikvah K., Kolodner, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974649/
https://www.ncbi.nlm.nih.gov/pubmed/24699249
http://dx.doi.org/10.1371/journal.pgen.1004277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974649/
https://www.ncbi.nlm.nih.gov/pubmed/24699249
http://dx.doi.org/10.1371/journal.pgen.1004277

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