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Identification of Two Tyrosine Residues Required for the Intramolecular Mechanism Implicated in GIT1 Activation

GIT1 is an ArfGAP and scaffolding protein regulating cell adhesion and migration. The multidomain structure of GIT1 allows the interaction with several partners. Binding of GIT1 to some of its partners requires activation of the GIT1 polypeptide. Our previous studies indicated that binding of paxill...

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Detalles Bibliográficos
Autores principales: Totaro, Antonio, Astro, Veronica, Tonoli, Diletta, de Curtis, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974724/
https://www.ncbi.nlm.nih.gov/pubmed/24699139
http://dx.doi.org/10.1371/journal.pone.0093199