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The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?
The emergence of drug-resistant pathogens poses a major threat to public health. Although influenced by multiple factors, high-level resistance is often associated with mutations in target-encoding or related genes. The fitness cost of these mutations is, in turn, a key determinant of the spread of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975073/ https://www.ncbi.nlm.nih.gov/pubmed/26038512 http://dx.doi.org/10.1038/emi.2014.17 |