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Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs

Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length. The enzyme telomerase replenishes the ends of telomeres and thus prolongs the life span of ce...

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Detalles Bibliográficos
Autores principales: Hirt, Bartholomäus V., Wattis, Jonathan A. D., Preston, Simon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975128/
https://www.ncbi.nlm.nih.gov/pubmed/23620229
http://dx.doi.org/10.1007/s00285-013-0678-2