The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIV(SF162P3N) infection

BACKGROUND: Severe genetic bottleneck occurs during HIV-1 sexual transmission whereby most infections are initiated by a single transmitted/founder (T/F) virus. Similar observations had been made in nonhuman primates exposed mucosally to SIV/SHIV. We previously reported variable clinical outcome in...

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Detalles Bibliográficos
Autores principales: Tsai, Lily, Tasovski, Ivan, Leda, Ana Rachel, Chin, Mario PS, Cheng-Mayer, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975242/
https://www.ncbi.nlm.nih.gov/pubmed/24612462
http://dx.doi.org/10.1186/1742-4690-11-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975242/
https://www.ncbi.nlm.nih.gov/pubmed/24612462
http://dx.doi.org/10.1186/1742-4690-11-22

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