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Profile of vintafolide (EC145) and its use in the treatment of platinum-resistant ovarian cancer
OBJECTIVE: Our aim was to review the profile of vintafolide (EC145) and its rationale for use in platinum-resistant ovarian cancer. First we investigated the folate receptors (FRs), folate’s pathway into cells, and its expression in normal and cancerous cells, before detailing the mechanism of actio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976235/ https://www.ncbi.nlm.nih.gov/pubmed/24729732 http://dx.doi.org/10.2147/IJWH.S39696 |