Ca(V)3.2 T-Type Calcium Channels in Peripheral Sensory Neurons Are Important for Mibefradil-Induced Reversal of Hyperalgesia and Allodynia in Rats with Painful Diabetic Neuropathy

We recently showed that streptozotocin (STZ) injections in rats lead to the development of painful peripheral diabetic neuropathy (PDN) accompanied by enhancement of Ca(V)3.2 T-type calcium currents (T-currents) and hyperexcitability in dorsal root ganglion (DRG) neurons. Here we used the classical...

Descripción completa

Detalles Bibliográficos
Autores principales: Obradovic, Aleksandar Lj., Hwang, Sung Mi, Scarpa, Joseph, Hong, Sung Jun, Todorovic, Slobodan M., Jevtovic-Todorovic, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976247/
https://www.ncbi.nlm.nih.gov/pubmed/24705276
http://dx.doi.org/10.1371/journal.pone.0091467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976247/
https://www.ncbi.nlm.nih.gov/pubmed/24705276
http://dx.doi.org/10.1371/journal.pone.0091467

Ejemplares similares