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Compromised paraspeckle formation as a pathogenic factor in FUSopathies

Paraspeckles are nuclear bodies formed by a set of specialized proteins assembled on the long non-coding RNA NEAT1; they have a role in nuclear retention of hyperedited transcripts and are associated with response to cellular stress. Fused in sarcoma (FUS) protein, linked to a number of neurodegener...

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Detalles Bibliográficos
Autores principales: Shelkovnikova, Tatyana A., Robinson, Hannah K., Troakes, Claire, Ninkina, Natalia, Buchman, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976330/
https://www.ncbi.nlm.nih.gov/pubmed/24334610
http://dx.doi.org/10.1093/hmg/ddt622