Complex I Deficiency Due to Selective Loss of Ndufs4 in the Mouse Heart Results in Severe Hypertrophic Cardiomyopathy

Mitochondrial complex I, the primary entry point for electrons into the mitochondrial respiratory chain, is both critical for aerobic respiration and a major source of reactive oxygen species. In the heart, chronic dysfunction driving cardiomyopathy is frequently associated with decreased complex I...

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Detalles Bibliográficos
Autores principales: Chouchani, Edward T., Methner, Carmen, Buonincontri, Guido, Hu, Chou-Hui, Logan, Angela, Sawiak, Stephen J., Murphy, Michael P., Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976382/
https://www.ncbi.nlm.nih.gov/pubmed/24705922
http://dx.doi.org/10.1371/journal.pone.0094157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976382/
https://www.ncbi.nlm.nih.gov/pubmed/24705922
http://dx.doi.org/10.1371/journal.pone.0094157

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