C-Terminal Modulatory Domain Controls Coupling of Voltage-Sensing to Pore Opening in Ca(v)1.3 L-type Ca(2+) Channels
Activity of voltage-gated Ca(v)1.3 L-type Ca(2+) channels is required for proper hearing as well as sinoatrial node and brain function. This critically depends on their negative activation voltage range, which is further fine-tuned by alternative splicing. Shorter variants miss a C-terminal regulato...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976517/ https://www.ncbi.nlm.nih.gov/pubmed/24703308 http://dx.doi.org/10.1016/j.bpj.2014.02.017 |