C-Terminal Modulatory Domain Controls Coupling of Voltage-Sensing to Pore Opening in Ca(v)1.3 L-type Ca(2+) Channels

Activity of voltage-gated Ca(v)1.3 L-type Ca(2+) channels is required for proper hearing as well as sinoatrial node and brain function. This critically depends on their negative activation voltage range, which is further fine-tuned by alternative splicing. Shorter variants miss a C-terminal regulato...

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Detalles Bibliográficos
Autores principales: Lieb, Andreas, Ortner, Nadine, Striessnig, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976517/
https://www.ncbi.nlm.nih.gov/pubmed/24703308
http://dx.doi.org/10.1016/j.bpj.2014.02.017