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Selective propagation of functional mtDNA during oogenesis restricts the transmission of a deleterious mitochondrial variant
Though mitochondrial DNA is prone to mutation and few mtDNA repair mechanisms exist(1), crippling mitochondrial mutations are exceedingly rare(2). Recent studies demonstrated strong purifying selection in the mouse female germline(3,4). However, the mechanisms underlying the positive selection of he...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976679/ https://www.ncbi.nlm.nih.gov/pubmed/24614072 http://dx.doi.org/10.1038/ng.2920 |