5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity

Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid malignancies. 5-Aza enhances anticancer immunity, by increasing expression of tumor-associated antigens. However, the impact of 5-Aza immune responses remains poorly understood. Here, T-cell mediated tumo...

Descripción completa

Detalles Bibliográficos
Autores principales: Stübig, Thomas, Badbaran, Anita, Luetkens, Tim, Hildebrandt, York, Atanackovic, Djordje, Binder, Thomas M. C., Fehse, Boris, Kröger, Nicolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976863/
https://www.ncbi.nlm.nih.gov/pubmed/24757283
http://dx.doi.org/10.1155/2014/418292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976863/
https://www.ncbi.nlm.nih.gov/pubmed/24757283
http://dx.doi.org/10.1155/2014/418292

Ejemplares similares