The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer

We have recently demonstrated that the combination of gemcitabine and a superoxide dismutase mimetic protects mice against lung cancer by suppressing the functions of myeloid-derived suppressor cells and by activating memory CD8(+) T-cell responses. Persistent memory cells exhibited a glycolytic met...

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Autores principales: Sawant, Anandi, Schafer, Cara C, Ponnazhagan, Selvarangan, Deshane, Jessy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976979/
https://www.ncbi.nlm.nih.gov/pubmed/24711958
http://dx.doi.org/10.4161/onci.27401
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author Sawant, Anandi
Schafer, Cara C
Ponnazhagan, Selvarangan
Deshane, Jessy S
author_facet Sawant, Anandi
Schafer, Cara C
Ponnazhagan, Selvarangan
Deshane, Jessy S
author_sort Sawant, Anandi
collection PubMed
description We have recently demonstrated that the combination of gemcitabine and a superoxide dismutase mimetic protects mice against lung cancer by suppressing the functions of myeloid-derived suppressor cells and by activating memory CD8(+) T-cell responses. Persistent memory cells exhibited a glycolytic metabolism, which may have directly enhanced their effector functions. This combinatorial therapeutic regimen may reduce the propensity of some cancer patients to relapse.
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spelling pubmed-39769792014-04-07 The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer Sawant, Anandi Schafer, Cara C Ponnazhagan, Selvarangan Deshane, Jessy S Oncoimmunology Author's View We have recently demonstrated that the combination of gemcitabine and a superoxide dismutase mimetic protects mice against lung cancer by suppressing the functions of myeloid-derived suppressor cells and by activating memory CD8(+) T-cell responses. Persistent memory cells exhibited a glycolytic metabolism, which may have directly enhanced their effector functions. This combinatorial therapeutic regimen may reduce the propensity of some cancer patients to relapse. Landes Bioscience 2014-01-01 /pmc/articles/PMC3976979/ /pubmed/24711958 http://dx.doi.org/10.4161/onci.27401 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sawant, Anandi
Schafer, Cara C
Ponnazhagan, Selvarangan
Deshane, Jessy S
The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer
title The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer
title_full The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer
title_fullStr The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer
title_full_unstemmed The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer
title_short The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer
title_sort dual targeting of immunosuppressive cells and oxidants promotes effector and memory t-cell functions against lung cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976979/
https://www.ncbi.nlm.nih.gov/pubmed/24711958
http://dx.doi.org/10.4161/onci.27401
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