Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth

We have recently demonstrated that a DNA vaccine targeting membrane-bound KIT ligand (KITL) inhibits tumor growth by interfering with vessel stabilization/permeability and by disrupting the recruitment of inflammatory cells and regulatory T cells, the latter being an essential mechanism by which tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Dentelli, Patrizia, Cavallo, Federica, Brizzi, Maria Felice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976984/
https://www.ncbi.nlm.nih.gov/pubmed/24711955
http://dx.doi.org/10.4161/onci.27259
_version_ 1782310362881720320
author Dentelli, Patrizia
Cavallo, Federica
Brizzi, Maria Felice
author_facet Dentelli, Patrizia
Cavallo, Federica
Brizzi, Maria Felice
author_sort Dentelli, Patrizia
collection PubMed
description We have recently demonstrated that a DNA vaccine targeting membrane-bound KIT ligand (KITL) inhibits tumor growth by interfering with vessel stabilization/permeability and by disrupting the recruitment of inflammatory cells and regulatory T cells, the latter being an essential mechanism by which tumors resist available treatments. Combining KITL-targeting vaccines with conventional chemotherapy might avert drug resistance and improve the efficacy of standard-of-care therapeutic interventions.
format Online
Article
Text
id pubmed-3976984
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-39769842014-04-07 Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth Dentelli, Patrizia Cavallo, Federica Brizzi, Maria Felice Oncoimmunology Author's View We have recently demonstrated that a DNA vaccine targeting membrane-bound KIT ligand (KITL) inhibits tumor growth by interfering with vessel stabilization/permeability and by disrupting the recruitment of inflammatory cells and regulatory T cells, the latter being an essential mechanism by which tumors resist available treatments. Combining KITL-targeting vaccines with conventional chemotherapy might avert drug resistance and improve the efficacy of standard-of-care therapeutic interventions. Landes Bioscience 2014-01-01 /pmc/articles/PMC3976984/ /pubmed/24711955 http://dx.doi.org/10.4161/onci.27259 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Dentelli, Patrizia
Cavallo, Federica
Brizzi, Maria Felice
Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
title Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
title_full Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
title_fullStr Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
title_full_unstemmed Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
title_short Membrane-bound KIT ligand-targeting DNA vaccination inhibits mammary tumor growth
title_sort membrane-bound kit ligand-targeting dna vaccination inhibits mammary tumor growth
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976984/
https://www.ncbi.nlm.nih.gov/pubmed/24711955
http://dx.doi.org/10.4161/onci.27259
work_keys_str_mv AT dentellipatrizia membraneboundkitligandtargetingdnavaccinationinhibitsmammarytumorgrowth
AT cavallofederica membraneboundkitligandtargetingdnavaccinationinhibitsmammarytumorgrowth
AT brizzimariafelice membraneboundkitligandtargetingdnavaccinationinhibitsmammarytumorgrowth

Ejemplares similares