Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-Like Kinases (TLKs). Here, we identify TLK phosphorylation sites by mass spectrometry and...

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Detalles Bibliográficos
Autores principales: Klimovskaia, Ilnaz M, Young, Clifford, Strømme, Caroline B, Menard, Patrice, Jasencakova, Zuzana, Mejlvang, Jakob, Ask, Katrine, Ploug, Michael, Nielsen, Michael L, Jensen, Ole N, Groth, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977046/
https://www.ncbi.nlm.nih.gov/pubmed/24598821
http://dx.doi.org/10.1038/ncomms4394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977046/
https://www.ncbi.nlm.nih.gov/pubmed/24598821
http://dx.doi.org/10.1038/ncomms4394

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