Design, Synthesis and Biological Evaluation of 5-Oxo-1,4,5,6,7,8 Hexahydroquinoline Derivatives as Selective Cyclooxygenase-2 Inhibitors

A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO(2)), were designed for evaluat...

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Detalles Bibliográficos
Autores principales: Zarghi, Afshin, Sabakhi, Iman, Topuzyan, Vigen, Hajimahdi, Zahra, Daraie, Bahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977054/
https://www.ncbi.nlm.nih.gov/pubmed/24711830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977054/
https://www.ncbi.nlm.nih.gov/pubmed/24711830

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