Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

[Image: see text] Many structurally and therapeutically diverse drugs interact with the human heart K(+) channel hERG by binding within the K(+) permeation pathway of the open channel, leading to drug-induced ‘long QT syndrome’. Drug binding to hERG is often stabilized by inactivation gating. In the...

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Detalles Bibliográficos
Autores principales: Dempsey, Christopher E., Wright, Dominic, Colenso, Charlotte K., Sessions, Richard B., Hancox, Jules C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977586/
https://www.ncbi.nlm.nih.gov/pubmed/24471705
http://dx.doi.org/10.1021/ci400707h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977586/
https://www.ncbi.nlm.nih.gov/pubmed/24471705
http://dx.doi.org/10.1021/ci400707h

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